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    Digital light processing (DLP) 3D-fabricated antimicrobial hydrogel with a sustainable resin of methacrylated woody polysaccharides and hybrid silver-lignin nanospheres

    Year: 2022

    Journal: Green Chem., Volume 24, MAR 9, page 2129–2145

    Authors: Wang, Luyao; Wang, Qingbo; Slita, Anna; Backman, Oskar; Gounani, Zahra; Rosqvist, Emil; Peltonen, Jouko; Willfor, Stefan; Xu, Chunlin; Rosenholm, Jessica M.; Wang, Xiaoju

    Organizations: China Scholarship Council [201804910639, 201907960002]; Academy of Finland [333158]; Jane and Aatos Erkko Foundation; Business Finland Project [43674/31/2020]; Sigrid Juselius Foundation; Medicinska Understodsforeningen Liv och Halsa r.f. and Magnus Ehrnrooth Foundation; Biocenter Finland; Academy of Finland (AKA) [333158] Funding Source: Academy of Finland (AKA)

    Lithography-based digital light processing (DLP) 3D printing has gained increasing interest in the fabrication of custom-designed hydrogel scaffolds. Current research development calls for the versatility of the bio-based resin formulations that deliver a suitable printability for fabricating biomedical hydrogel using DLP printing. Here, a bio-based antimicrobial resin was developed for DLP printing engaging the methacrylated O-acetyl-galactoglucomannan (GGMMA) as a photo-crosslinkable polymeric matrix and the nanocomposite lignin nanoparticles that are surface-embedded with silver nanoparticles (LNP@Ags) as a high-performance antimicrobial reagent. The alkali-resistance of LNPs as demanded for in situ reduction of silver nanoparticles (AgNPs) from silver ammonia solution (pH 11) was achieved by upgrading the technical lignin via a combination of lignin solvent fractionation with laccase-catalyzed polymerization. The dimension of the as-prepared LNPs (in the range of 120-290 nm) and the content of residual phenolic hydroxyl and methoxyl groups for reducing Ag+ could be modulated by tuning the laccase-catalyzed lignin polymerization degree. The encapsulation of nanocomposite LNP@Ag into the GGMMA hydrogel did not significantly alter the gelation rate of the GGMMA/LNP@Ag resin and the mechanical property of the resulted hydrogel, when the dosage of LNP@Ag was less than 0.1 wt% in 10 wt% GGMMA. The GGMMA/LNP@Ag hydrogel also possesses high antimicrobial activity due to the bactericidal ability of Ag+ that was leached out of the hydrogel in a sustained manner. Upon the layer-by-layer photocuring in DLP printing, the GGMMA/LNP@Ag resin allowed us to fabricate hydrogel constructs, including honeycomb and crosshatch with good structural stability and printing fidelity. This study proposes a green and effective fabrication route for LNP supported AgNPs as well as a novel case study for a sustainable resin suitable for DLP 3D hydrogel printing.
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