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    Dressing Blood-Contacting Materials by a Stable Hydrogel Coating with Embedded Antimicrobial Peptides for Robust Antibacterial and Antithrombus Properties

    Year: 2021

    Journal: ACS Appl. Mater. Interfaces, Volume 13, AUG 25, page 38947–38958

    Authors: Liu, Kunpeng; Zhang, Fanjun; Wei, Yuan; Hu, Qinsheng; Luo, Qingfeng; Chen, Chong; Wang, Jingyu; Yang, Li; Luo, Rifang; Wang, Yunbing

    Organizations: Sichuan Science and Technology Program [2021YFH0011]; National Key Research and Development Program [2016YFC1102200]; 111 Project (the Program of Introducing Talents of Discipline to Universities) [B16033]; Initiation Funding for Interdisciplinary Research of Sichuan University [0040204153251]; Sichuan Science and Technology Major Project [2018SZDZX0011]

    Keywords: antimicrobial peptides; hydrogel coating; hemocompatibility; antibacterial; blood-contacting devices

    Although dressing blood-contacting devices with robust and synergistic antibacterial and antithrombus properties has been explored for several decades, it still remains a great challenge. In order to endow materials with remarkable antibacterial and antithrombus abilities, a stable and antifouling hydrogel coating was developed via surface-initiated polymerization of sulfobetaine methacrylate and acrylic acid on a polymeric substrate followed by embedding of antimicrobial peptides (AMPs), including WR (sequence: WRWRWR-NH2) or Bac2A (sequence: RLARIVVIRVAR-NH2) AMPs. The chemical composition of the AMP-embedded hydrogel coating was determined through XPS, zeta potential, and SEM-EDS measurements. The AMP-embedded antifouling hydrogel coating showed not only good hemocompatibility but also excellent bactericidal and antiadhesion properties against Gram-positive and Gram-negative bacteria. Moreover, the hydrogel coating could protect the AMPs with long-term bioactivity and cover the positive charge of the dotted distributed AMPs, which in turn well retained the hemocompatibility and antifouling capacity of the bulk hydrogels. Furthermore, the microbiological results of animal experiments also verified the anti-infection performance in vivo. Histological and immunological data further indicated that the hydrogel coating had an excellent anti-inflammatory function. Therefore, the present study might provide a promising approach to prevent bacterial infections and thrombosis in clinical applications of blood-contacting devices and related implants.
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