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    Dynamic Titania Nanotube Surface Achieves UV-Triggered Charge Reversal and Enhances Cell Differentiation

    Year: 2019

    Journal: ACS Appl. Mater. Interfaces, Volume 11, OCT 9, page 36939–36948

    Authors: Bai, Jun; Zuo, Xingang; Feng, Xue; Sun, Yunfeng; Ge, Qunzi; Wang, Xuemei; Gao, Changyou

    Keywords: TiO2 nanotubes; stimuli-responsive biomaterials; UV-radiation; pH modulation; stem cells

    Stimuli-responsive biomaterials supply a promising solution to adapt to the complex physiological environment for different biomedical applications. In this study, a dynamic UV-triggered pH-responsive biosurface was constructed on titania nanotubes (TNTs) by loading photoacid generators, diphenyliodonium chloride, into the nanotubes, and grafting 2,3-dimethyl maleic anhydride (DMMA)-modified hyperbranched poly(L-lysine) (HBPLL) onto the surface. The local acidity was dramatically enhanced by UV irradiation for only 30 s, leading to the dissociation of DMMA and thereby the transformation of surface chemistry from negatively charged caboxyl groups to positively charged amino groups. The TNTs-HBPLL-DMMA substrate could better promote proliferation and spreading of rat bone mesenchymal stem cells (rBMSCs) after UV irradiation. The osteogenic differentiation of rBMSCs was enhanced because of the charge reversal in combination with the titania-based substrates.
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