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    Electron-Beam Irradiation of the PLLA/CMS/beta-TCP Composite Nanofibers Obtained by Electrospinning

    Year: 2020

    Journal: Polymers, Volume 12, JUL

    Authors: Yusof, Mohd Reusmaazran; Shamsudin, Roslinda; Zakaria, Sarani; Hamid, Muhammad Azmi Abdul; Yalcinkaya, Fatma; Abdullah, Yusof; Yacob, Norzita

    Organizations: Universiti Kebangsaan Malaysia, Ministry of Higher Education [FRGS/1/2018/STG07/UKM/02/03]; Ministry of Education, Youth and Sports of the Czech RepublicMinistry of Education, Youth & Sports - Czech Republic [CZ.02.1.01/0.0/0.0/16_019/0000843]; European Union - European Structural and Investment Funds in the frames of Operational Program Research, Development and Education - project Hybrid Materials for Hierarchical Structures (HyHi) [CZ.02.1.01/0.0/0.0/16_019/0000843]

    Keywords: PLLA; carboxy-methyl starch; beta-tricalcium phosphate; electrospun; biodegradation

    Nanofibrous materials produced by electrospinning processes have potential advantages in tissue engineering because of their biocompatibility, biodegradability, biomimetic architecture, and excellent mechanical properties. The aim of the current work is to study the influence of the electron beam on the poly L-lactide acid/ carboxy-methyl starch/beta-tricalcium phosphate (PLLA/CMS/beta-TCP) composite nanofibers for potential applications as bone-tissue scaffolds. The composite nanofibers were prepared by electrospinning in the combination of 5%v/vcarboxy-methyl starch (CMS) and 0.25 wt% of beta-TCP with the PLLA as a matrix component. The composites nanofibers were exposed under 5, 30, and 100 kGy of irradiation dose. The electron-beam irradiation showed no morphological damage to the fibers, and slight reduction in the water-contact angle and mechanical strength at the higher-irradiation doses. The chain scission was found to be a dominant effect; the higher doses of electron-beam irradiation thus increased the in vitro degradation rate of the composite nanofibers. The chemical interaction due to irradiation was indicated by the Fourier transform infrared (FTIR) spectrum and thermal behavior was investigated by a differential scanning calorimeter (DSC). The results showed that the electron-beam-induced poly L-lactide acid/carboxy-methyl starch/beta-tricalcium phosphate (PLLA/CMS/beta-TCP) composite nanofibers may have great potential for bone-tissue engineering.
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