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    Enhancing anti-thrombogenicity of biodegradable polyurethanes through drug molecule incorporation

    Year: 2018

    Journal: J. Mat. Chem. B, Volume 6, NOV 28, page 7288–7297

    Authors: Xu, Cancan; Kuriakose, Aneetta E.; Truong, Danh; Punnakitikashem, Primana; Nguyen, Kytai T.; Hong, Yi

    Organizations: CAREER award from the National Science Foundation [1554835]; National Institutes of Health in the United States [R21HD090680, R01HL118498, T32 HL134613]

    Sufficient and sustained anti-thrombogenicity is essential for blood-contacting materials because blood coagulation and thrombosis caused by platelet adhesion and activation on material surfaces may lead to functional failure and even fatal outcomes. Covalently conjugating anti-thrombogenic moieties into a polymer, instead of surface modification or blending, can maintain the anti-thrombogenicity of the polymer at a high level over time. In this study, a series of randomly crosslinked, elastic, biodegradable polyurethanes (PU-DPA) were synthesized through a one-pot and one-step method from polycaprolactone (PCL) diol, hexamethylene diisocyanate (HDI) and an anti-thrombogenic drug, dipyridamole (DPA). The mechanical properties, hydrophilicity, in vitro degradation, and anti-thrombogenicity of the resultant PU-DPA polymers could be tuned by altering the incorporated DPA amount. The surface and bulk hydrophilicity of the polyurethanes decreased with increasing hydrophobic DPA amounts. All PU-DPA polymers exhibited strong mechanical properties and good elasticity. The degradation rates of PU-DPAs decreased with increasing DPA content in both PBS and lipase/PBS solutions. Covalently incorporating DPA into the polyurethane significantly reduced the platelet deposition compared to that of the polyurethane without DPA, and the polyurethane remained anti-thrombogenicity after degradation. The PU-DPA films also supported the growth of human umbilical vein endothelial cells. The attractive mechanical properties, blood compatibility, and cell compatibility of this anti-thrombogenic biodegradable polyurethane indicate that it has a great potential to be utilized for blood-contacting devices and cardiovascular tissue repair and regeneration.
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