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    Evaluation of Emulsifying Ability of Phospholipids by Langmuir Monolayers and Stability of High Oil Ratio O/W Emulsions

    Year: 2022

    Journal: AAPS PharmSciTech, Volume 23, JUL 28

    Authors: Li, Shanghui; Zhang, Bing; Chang, Minsi; Zhang, Ruirong; Liu, Bei; Yin, Tian; Zhang, Yu; He, Haibing; Gou, Jingxin; Wang, Yanjiao; Tang, Xing

    Organizations: National Mega-project for Innovative Drugs [2019ZX09721001]; National Key R&D Program of China [2020YFE0201700]; Liaoning Revitalization Talents Program [XLYC1908031]

    Keywords: phospholipid; langmuir monolayers; emulsifying ability; stability

    High oil ratio fat emulsion injections are prone to poor emulsification, rapid creaming, and other quality problems; therefore, the selection of emulsifiers with high emulsifying ability is crucial for the production of fat emulsions. The existing methods used to evaluate the emulsifying ability of emulsifier are to evaluate the emulsifying ability from the emulsifier itself. In the study, Langmuir monolayer selected the most miscible phospholipid with oil phase from the alternative three phospholipids by studying the molecular interaction between oil phase and phospholipid at the air/water interface. The miscibility and thermodynamic stability analyses of the different oil phase/phospholipid mixed monolayers were performed, and the data from Delta A(exc) and Delta G(ex) concluded that all three oil phases had the strongest molecular interaction with E80 and the best miscibility. The emulsions were then prepared and analyzed by the results of particle size, zeta-potential, and stability of the emulsions, where the surface free energy in the stability test echoed the results reflected by the Delta G(ex) values in the thermodynamic stability test. These results indicate that Langmuir monolayers can be used to study the interaction between oil phase and emulsifier, thus providing new ideas for evaluating the emulsifying ability of phospholipids.
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