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    Evaluation of Physicochemical Properties of Amphiphilic 1,4-Dihydropyridines and Preparation of Magnetoliposomes

    Year: 2021

    Journal: Nanomaterials, Volume 11, MAR

    Authors: Petrichenko, Oksana; Plotniece, Aiva; Pajuste, Karlis; Rucins, Martins; Dimitrijevs, Pavels; Sobolev, Arkadij; Sprugis, Einars; Cebers, Andrejs

    Organizations: PostDocLatvia Project [1.1.1.2/VIAA/1/16/018, 1.1.1.2/VIAA/2/18/371]; LIOS internal grant [IG-2018-13]; M.era-net project FMF [1.1.1.5/ERANET/18/04]

    Keywords: 1; 4-dihydropyridine amphiphiles; iron oxide nanoparticles; magnetoliposomes; lipid monolayers; physicochemical properties

    This study was focused on the estimation of the targeted modification of 1,4-DHP core with (1) different alkyl chain lengths at 3,5-ester moieties of 1,4-DHP (C-12, C-14 and C-16); (2) N-substituent at position 1 of 1,4-DHP (N-H or N-CH3); (3) substituents of pyridinium moieties at positions 2 and 6 of 1,4-DHP (H, 4-CN and 3-Ph); (4) substituent at position 4 of 1,4-DHP (phenyl and napthyl) on physicochemical properties of the entire molecules and on the characteristics of the obtained magnetoliposomes formed by them. It was shown that thermal behavior of the tested 1,4-DHP amphiphiles was related to the alkyl chains length, the elongation of which decreased their transition temperatures. The properties of 1,4-DHP amphiphile monolayers and their polar head areas were determined. The packing parameters of amphiphiles were in the 0.43-0.55 range. It was demonstrated that the structure of 1,4-DHPs affected the physicochemical properties of compounds. Empty liposomes and magnetoliposomes were prepared from selected 1,4-DHP amphiphiles. It was shown that the variation of alkyl chains length or the change of substituents at positions 4 of 1,4-DHP did not show a significant influence on properties of liposomes.
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