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    Fabrication of hollow microneedles using liquid crystal display (LCD) vat polymerization 3D printing technology for transdermal macromolecular delivery

    Year: 2021

    Journal: Int. J. Pharm., Volume 597, MAR 15

    Authors: Xenikakis, Iakovos; Tsongas, Konstantinos; Tzimtzimis, Emmanouil K.; Zacharis, Constantinos K.; Theodoroula, Nikoleta; Kalogianni, Eleni P.; Demiri, Euterpi; Vizirianakis, Ioannis S.; Tzetzis, Dimitrios; Fatouros, Dimitrios G.

    Keywords: Hollow Microneedle Device; Liquid Crystal Display; Skin synthetic membrane; Finite Element Analysis; Mechanical testing; Octreotide-acetate

    The present study aimed to fabricate a hollow microneedle device consisting of an array and a reservoir by means of 3D printing technology for transdermal peptide delivery. Hollow microneedles (HMNs) were fabricated using a biocompatible resin material, while PLA filament was used for the reservoirs. The fabricated microdevice was characterized by means of optical microscopy, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), contact angle measurements and leakage inspection studies to ensure the passageway of liquid formulations. Mechanical failure and penetration tests were carried out and supported by Finite Element Analysis (FEA). The cytocompatibility of the microneedle arrays was assessed to human keratinocytes (HaCaT). Finally, the transport of the model peptide octreotide acetate across artificial membranes was assessed in Franz cells using the aforementioned HMN design.
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