Contact
    Start Publications Facile fabrication of carboxymethyl chitosan/paraffin coated ...
    ←  Publication Finder
    Attension

    Facile fabrication of carboxymethyl chitosan/paraffin coated carboxymethylated cotton fabric with asymmetric wettability for hemostatic wound dressing

    Year: 2020

    Journal: Cellulose, Volume 27, APR, page 3443–3453

    Authors: Wang, Yamei; Xiao, Dongdong; Zhong, Yi; Zhang, Linping; Chen, Zhize; Sui, Xiaofeng; Wang, Bijia; Feng, Xueling; Xu, Hong; Mao, Zhiping

    Organizations: Taishan Industrial Leading Talents Project Special Funds of Shandong Province, China; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21872025]

    Keywords: Cellulose; Paraffin; Janus; Hemostatic wound dressing; Blood loss

    Achieving effective hemostasis is significant to ensure the survival of the people with acute massive bleeding in the battlefield or daily life in pre-hospital care. In this work, modified cotton fabric with asymmetric wettability (Janus) was prepared using a fast and simple spray-coating strategy, where, one side of the fabric was sprayed with carboxymethyl chitosan solution to achieve hydrophilicity (0 degrees) while the other side with hydrophobicity (152 degrees) was built using paraffin. The hydrophilic surface could provide blood absorption and promote hemostasis, while the hydrophobic surface prevented the excessive blood absorption. The hemostatic efficiency of fabrics was tested in vitro and in vivo. Here, the carboxymethyl chitosan coated carboxymethylated cotton (CS-MCF) and Janus showed better hemostatic capacity than the cotton fabric (CF) in vitro with the lower blood clotting index. Furthermore, the Janus had better hemostatic performance than CF in rat liver animal model, and prolonged the survival time of the rats in carotid artery animal model. Therefore, Janus, with superior hemostatic efficiency over the cotton fabric, has a bright application prospect as hemostatic wound dressing. [GRAPHICS] .
    View publication