Contact
    Start Publications Facile Method for Surface-Grafted Chitooligosaccharide on ...
    ←  Publication Finder
    Attension

    Facile Method for Surface-Grafted Chitooligosaccharide on Medical Segmented Poly(ester-urethane) Film to Improve Surface Biocompatibility

    Year: 2021

    Journal: Membranes, Volume 11, JAN

    Authors: Liu, Yifan; Liu, Zhengqi; Gao, Ya; Gao, Weiwei; Hou, Zhaosheng; Zhu, Yuzheng

    Organizations: Shandong Provincial Natural Science Foundation, China [ZR2018MEM024]; Scientific Research Fund Project of Undergraduates, Shandong Normal University, China [BKJJ2020050]

    Keywords: segmented poly(ester-urethane); chitooligosaccharide; surface grafting; biocompatibility

    In the paper, the chitooligosaccharide (CHO) was surface-grafted on the medical segmented poly(ester-urethane) (SPU) film by a facile two-step procedure to improve the surface biocompatibility. By chemical treatment of SPU film with hexamethylene diisocyanate under mild reaction condition, free -NCO groups were first introduced on the surface with high grafting density, which were then coupled with -NH2 groups of CHO to immobilize CHO on the SPU surface (SPU-CHO). The CHO-covered surface was characterized by FT-IR and water contact angle test. Due to the hydrophilicity of CHO, the SPU-CHO possessed higher surface hydrophilicity and faster hydrolytic degradation rate than blank SPU. The almost overlapping stress-strain curves of SPU and SPU-CHO films demonstrated that the chemical treatments had little destruction on the intrinsic properties of the substrate. In addition, the significant inhibition of platelet adhesion and protein adsorption on CHO-covered surface endowed SPU-CHO an outstanding surface biocompatibility (especially blood compatibility). These results indicated that the CHO-grafted SPU was a promising candidate as blood-contacting biomaterial for biomedical applications.
    View publication