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    Folding of cytosine-based nucleolipid monolayer by guanine recognition at the air-water interface

    Year: 2019

    Journal: J. Colloid Interface Sci., Volume 537, MAR 1, page 694–703

    Authors: Argudo, Pablo G.; Munoz, Eulogia; Jose Giner-Casares, Juan; Teresa Martin-Romero, Maria; Camacho, Luis

    Organizations: Ministry of Economy and Competitiveness of Spain [CTQ2014-57515-C2, CTQ2017-83961-R]; Ministry of Economy and Competitiveness [RyC-2014-14956]

    Keywords: Langmuir monolayer; Cytosine-based nucleolipid; Computer simulations; Complementary base pairing

    Monolayers of a cytosine-based nucleolipid (1,2-dipalmitoyl-sn-glycero-3-(cytidine diphosphate) (ammonium salt), CDP-DG) at basic subphase have been prepared at the air-water interface both in absence and presence of guanine. The formation of the complementary base pairing is demonstrated by combining surface experimental techniques, i.e., surface pressure (pi)-area (A), Brewster angle microscopy (BAM), infrared spectroscopy (PM-IRRAS) and computer simulations. A folding of the cytosine-based nucleolipid molecules forming monolayer at the air-water interface occurs during the guanine recognition as absorbate host and is kept during several compression-expansion processes under set experimental conditions. The specificity between nitrogenous bases has been also registered. Finally, mixed monolayers of CDP-DG and a phospholipid (1,2-dimyristoyl-sn-glycero-3-phosphate (sodium salt), DMPA) has been studied and a molecular segregation of the DMPA molecules has been inferred by the additivity rule. (C) 2018 Elsevier Inc. All rights reserved.
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