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    Functionalization of PTFE Materials Using a Combination of Polydopamine and Platelet-Rich Fibrin

    Year: 2020

    Journal: J. Surg. Res., Volume 251, JUL, page 254–261

    Authors: Talon, Isabelle; Schneider, Anne; Ball, Vincent; Hemmerle, Joseph

    Organizations: FIMATHO association

    Keywords: PTFE; Congenital diaphragmatic hernia; Polydopamine; PRF; Biomaterial

    Background: The diaphragm, which forms a physical barrier between the thoracic and the abdominal cavities, is also the major part of the respiratory system. Congenital diaphragmatic hernia (CDH) is a malformation of that partition muscle. Expanded polytetrafluoroethylene (e-PTFE), a synthetic nondegradable biomaterial, is currently used for the repair of diaphragm defects. Indeed, this hydrophobic biomaterial does not promote rapid and dense cell colonization. Surface modifications are needed to favor or even guide cellular responses. Materials and methods: In this context, we present here a practical and effective way of functionalization of the e-PTFE material. We investigated, by using electron microscopy, the coating with PRF (Platelet-Rich Fibrin) of PDA (Polydopamine) treated e-PTFE implant material. Results: We demonstrate that this straightforward chemical functionalization with PDA increases the hydrophilicity of e-PTFE and thus improves tissue integration. Then, we demonstrated that whatever the contact time between PRF and e-PTFE and the centrifugation speed, the PDA coating on the e-PTFE biomaterial promotes further biological events like cell adhesion and spreading. Conclusions: Our findings clearly show that this composite coating (chemically by using PDA thorn biologically by using PRF) method of e-PTFE is a simple, interesting and promising way to favor tissular integration of such biomaterials. (C) 2019 Elsevier Inc. All rights reserved.
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