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    Genistein carbon dots exhibit antioxidant and anti-inflammatory effects in vitro

    Year: 2023

    Journal: Colloids and Surfaces B: Biointerfaces, Volume 223, 2023-03-01, page 113173

    Authors: Jaiswal, Kumar Sagar; Malka, Orit; Shauloff, Nitzan; Bersudsky, Marina; Voronov, Elena; Gupta, Bhawna; Jelinek, Raz

    Keywords: Anti-inflammation; Antioxidants; Carbon dots; Genistein; Isoflavone; Phytochemicals

    Genistein, an isoflavone from soybean, has attracted attention due to its health benefits, particularly antioxidant and anti-inflammatory activities. Clinical applications of genistein, however, have been limited due to the considerable hydrophobicity and lower bioavailability of the molecule. In this study, carbon dots (C-dots) synthesized from genistein as the carbonaceous precursor exhibit antioxidant properties in test-tube and cell experiments. Anti-inflammatory activity of the genistein-C-dots was also recorded in LPS stimulated macrophages, manifested in inhibition of pro-inflammatory cytokine levels and enhancement anti-inflammatory cytokine expression. The antioxidant and anti-inflammatory effects of the genistein-C-dots, particularly in comparison to the parent genistein molecules, likely account to the display of functional genistein residues on the C-dots’ surfaces, and low band gap energy facilitating electron scavenging. Importantly, the genistein-C-dots featured biocompatibility and low cytotoxicity, underlining their potential as a therapeutic vehicle against inflammatory conditions.
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