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    Green cationic arginine surfactants: Influence of the polar head cationic character on the self-aggregation and biological properties

    Year: 2021

    Journal: J. Mol. Liq., Volume 339, OCT 1

    Authors: Perez, Lourdes; Pons, Ramon; Oliveira de Sousa, Francisco Fabio; Moran, Maria del Carmen; da Silva, Anderson Ramos; Pinazo, Aurora

    Organizations: Ministerio de Economia y Competitividad, Spain [CTQ 2017 - 88948 - P]; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]; National Program of Cooperation in the Amazon - PROCAD/Amazon of Coordination of Superior Level Staff Improvement - CAPES/Brazil

    Keywords: Arginine; Surfactants; Monolayer; Liquid Crystals; Antimicrobial; Antibiofilm

    Green surfactants are compounds derived from renewable sources of raw material that exhibit biodegradability and low toxicity. In this work the synthesis, solution, aggregation and biological properties of two families of green cationic arginine based surfactants have been investigated, Na-acyl arginine methyl ester and arginine N-alkyl amide. Specifically we study: (i) the effect of self-aggregation on the cationic character, (ii) Liquid crystalline phases applying SAXS, (iii) surfactant ability to interact with biological membranes using Langmuir DPPC monolayers as a simple membrane model, (iv) biological profiles obtained by evaluation of antibacterial, anti-yeast and antibiofilm properties and, (v) the hemolytic activity on erythrocytes. The experiments conducted showed that the biological properties of arginine based surfactants were outstanding. These along with the fact that they are derived from green raw materials confer to these surfactants an outstanding potential in the field of green antimicrobial and antibiofilm agents. Published by Elsevier B.V.
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