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    Green Synthesis of Silver Nanoparticles Using Extract of Cilembu Sweet Potatoes (Ipomoea batatas L var. Rancing) as Potential Filler for 3D Printed Electroactive and Anti-Infection Scaffolds

    Year: 2021

    Journal: Molecules, Volume 26, APR

    Authors: Wibowo, Arie; Tajalla, Gusti U. N.; Marsudi, Maradhana A.; Cooper, Glen; Asri, Lia A. T. W.; Liu, Fengyuan; Ardy, Husaini; Bartolo, Paulo J. D. S.

    Organizations: Research, Community Service, and Innovation (P2MI) 2021 scheme from the Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung (ITB)

    Keywords: 3D printing; anti-infection scaffold; bone tissue engineering; Cilembu sweet potato; electroactive scaffold; green synthesis; silver nanoparticles

    Electroactive biomaterials are fascinating for tissue engineering applications because of their ability to deliver electrical stimulation directly to cells, tissue, and organs. One particularly attractive conductive filler for electroactive biomaterials is silver nanoparticles (AgNPs) because of their high conductivity, antibacterial activity, and ability to promote bone healing. However, production of AgNPs involves a toxic reducing agent which would inhibit biological scaffold performance. This work explores facile and green synthesis of AgNPs using extract of Cilembu sweet potato and studies the effect of baking and precursor concentrations (1, 10 and 100 mM) on AgNPs' properties. Transmission electron microscope (TEM) results revealed that the smallest particle size of AgNPs (9.95 +/- 3.69 nm) with nodular morphology was obtained by utilization of baked extract and ten mM AgNO3. Polycaprolactone (PCL)/AgNPs scaffolds exhibited several enhancements compared to PCL scaffolds. Compressive strength was six times greater (3.88 +/- 0.42 MPa), more hydrophilic (contact angle of 76.8 +/- 1.7 degrees), conductive (2.3 +/- 0.5 x 10(-3) S/cm) and exhibited anti-bacterial properties against Staphylococcus aureus ATCC3658 (99.5% reduction of surviving bacteria). Despite the promising results, further investigation on biological assessment is required to obtain comprehensive study of this scaffold. This green synthesis approach together with the use of 3D printing opens a new route to manufacture AgNPs-based electroactive with improved anti-bacterial properties without utilization of any toxic organic solvents.
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