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    Hierarchical Functionalized Polymeric-Ceramic Coatings on Mg-Ca Alloys for Biodegradable Implant Applications

    Year: 2019

    Journal: Macromol. Biosci., Volume 19, OCT

    Authors: Santos-Coquillat, Ana; Martinez-Campos, Enrique; Vargas-Alfredo, Nelson; Arrabal, Raul; Rodriguez-Hernandez, Juan; Matykina, Endzhe

    Organizations: ADITIMAT-CM Programme via Regional Government of Madrid [S2018/NMT-4411]; EU Structural Funds; European Social FundEuropean Social Fund (ESF) [PEJD-2018-POST/BMD-9592]; Spanish National Science Foundation (CSIC); Ministerio de Ciencia, Innovacion y Universidades, FONDOS FEDER [MAT2016-78437-R]; Regional Government of Madrid

    Keywords: biodegradable implants; breath figures; hierarchical structures; magnesium; polymer-inorganic hybrid coatings

    Magnesium-based implants present several advantages for clinical applications, in particular due to their biocompatibility and degradability. However, degradation products can affect negatively the cell activity. In this work, a combined coating strategy to control the implant degradation and cell regulation processes is evaluated, including plasma electrolytic oxidation (PEO) that produces a 13 mu m-thick Ca, P, and Si containing ceramic coating with surface porosity, and breath figures (BF) approach that produces a porous polymeric poly(epsilon-caprolactone) surface. The degradation of PCL-PEO-coated Mg hierarchical scaffold can be tailored to promote cell adhesion and proliferation into the porous structure. As a result, cell culture can colonize the inner PEO-ceramic coating structure where higher amount of bioelements are present. The Mg/PEO/PCL/BF scaffolds exhibit equally good or better premyoblast cell adhesion and proliferation compared with Ti CP control. The biological behavior of this new hierarchical functionalized scaffold can improve the implantation success in bone and cardiovascular clinical applications.
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