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    High-throughput toxicity study of lubricant emulsions and their common ingredients using zebrafish

    Year: 2018

    Journal: PLoS One, Volume 13, NOV 21

    Authors: Han, Jae-Hoon; Jung, Sang-Kyu

    Organizations: National Research Foundation of Korea (NRF) - Korean government (Ministry of Science, ICT & Future Planning) [NRF-2017R1C1B2004356]; Hongik University Research Fund

    Though lubricant emulsions have been widely used in many industrial processes, various human health hazards have been reported. Conducting a systematic toxicity study on emulsions is difficult since emulsions contain multiple chemical compounds, and hydrophobic compounds form complex emulsion particles via surfactants. For a quantitative toxicity study, we developed a high-throughput imaging system using zebrafish and conducted a large scale in vivo toxicity assay of lubricant emulsion and their common ingredients. By computing the locomotion activity of zebrafish from captured time-lapse images, we could quantify the degree of relative toxicity of 29 chemicals. The changes in the locomotion activity over time were observed to vary significantly depending on emulsions, indicating that the degree of toxicity of the commercial products was very diverse. We found that primary ethanolamines were more toxic than secondary or tertiary ethanolamines, and several factors, such as alkyl chain length, EO mole, test concentration, and emulsion particle size, affected toxicity.
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