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    Highly Stable Hierarchically Structured All-Polymeric Lubricant-Infused Films Prevent Thrombosis and Repel Multidrug-Resistant Pathogens

    Year: 2022

    Journal: ACS Appl. Mater. Interfaces, Volume 14, DEC 7, page 53535–53545

    Authors: Afonso, Elisabet; Bayat, Fereshteh; Ladouceur, Liane; Khan, Shadman; Martinez-Gomez, Aranzazu; Weitz, Jeffrey I.; Hosseinidoust, Zeinab; Tiemblo, Pilar; Garcia, Nuria; Didar, Tohid F.

    Organizations: Spanish Ministry of Science and Innovation for the FPI Grant [BES-2017-080057]; NSERC Discovery Grant; Ontario Early Researcher Award; McMaster Start-up funds

    Keywords: liquid-infused surfaces; omniphobic lubricant; hierarchically structured surfaces; antibacterial; antithrombogenic

    Thrombus formation and infections caused by bacterial adhesion are the most common causes of failure in blood-contacting medical devices. Reducing the interaction of pathogens using repellent surfaces has proven to be a successful strategy in preventing device failure. However, designing scale-up methodologies to create large-scale repellent surfaces remains challenging. To address this need, we have created an all-polymeric lubricant-infused system using an industrially viable swelling-coagulation solvent (S-C) method. This induces hierarchically structured micro/nano features onto the surface, enabling improved lubricant infusion. Poly(3,3,3-trifluoropropylmethylsiloxane) (PTFS) was used as the lubricant of choice, a previously unexplored omniphobic nonvolatile silicone oil. This resulted in all-polymeric liquid-infused surfaces that are transparent and flexible with long-term stability. Repellent properties have been demonstrated using human whole blood and methicillin-resistant Staphylococcus aureus (MRSA) bacteria matrices, with lubricated surfaces showing 93% reduction in blood stains and 96.7% reduction in bacterial adherence. The developed material has the potential to prevent blood and pathogenic contamination for a range biomedical devices within healthcare settings.
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