Contact
    Start Publications How the interaction of PVP-stabilized Ag nanoparticles with ...
    ←  Publication Finder
    KSV NIMA

    How the interaction of PVP-stabilized Ag nanoparticles with models of cellular membranes at the air-water interface is modulated by the monolayer composition

    Year: 2018

    Journal: J. Colloid Interface Sci., Volume 512, FEB 15, page 792–800

    Authors: Cruz Gomes da Silva, Rafael Leonardo; Oliveira da Silva, Heloiza Fernanda; da Silva Gasparotto, Luiz Henrique; Caseli, Luciano

    Organizations: FAPESP [2015/10253-0, 2015/09586-3]; CNPq [400896/2016-8, 442087/2014-4]

    Keywords: Silver nanoparticles; Langmuir monolayers; Air-water interface

    The antimicrobial property of silver nanoparticles (AgNPs) is believed to be associated to their interaction with biointerfaces such as microbial cell membranes, encouraging research on the identification of membrane sites capable of AgNPs binding. Although significant progress has been made in that regard, the exact molecular mechanism of action is yet to be fully understood. In this study, AgNPs dispersed in aqueous media and stabilized with polyvinylpyrrolidone were incorporated in Langmuir monolayers of selected lipids that served as cell membrane models. Results from pressure-area isotherms, vibrational spectroscopy and Brewster angle microscopy revealed condensation of glycoside-free lipid monolayers, evidencing that the AgNPs interact mostly with the lipid hydrophilic head groups. In contrast, the monolayers of systems containing glycoside derivatives were found to expand upon AgNPs incorporation, indicating that the glycosidic compounds might facilitate the incorporation of these nanoparticles in cellular membranes. These data can be therefore correlated with the possible toxicity and microbicide effect of AgNPs in lipidic surfaces of mammalian and microbial membranes. (C) 2017 Elsevier Inc. All rights reserved.
    View publication