Contact
    Start Publications Immobilization of a carbon nanomaterial-based localized ...
    ←  Publication Finder
    QSense

    Immobilization of a carbon nanomaterial-based localized drug-release system using a bispecific material-binding peptide

    Year: 2018

    Journal: Int. J. Nanomed., Volume 13, page 1643–1652

    Authors: Kokubun, Katsutoshi; Matsumura, Sachiko; Yudasaka, Masako; Iijima, Sumio; Shiba, Kiyotaka

    Keywords: drug carrier; drug delivery; carbon nanomaterial; carbon nanohorn; peptide aptamer

    Introduction: Inorganic materials are widely used in medical devices, such as artificial hearts, vessels, and joints, in stents, and as nanocarriers for drug-delivery systems. Carbon nano-materials are of particular interest due to their biological inertness and their capability to accommodate molecules. Several attempts have been proposed, in which carbon nanomaterials are used as nanocarriers for the systemic delivery of drugs. Materials and methods: We developed a drug-delivery system in which oxidized single-walled carbon nanohorns (oxSWNHs) were immobilized on a titanium (Ti) surface using material-binding peptides to enable localized drug delivery. For this purpose, we utilized a bispecific peptidic aptamer comprising a core sequence of a Ti-binding peptide and a SWNH-binding peptide to immobilize oxSWNHs on Ti. Results: Scanning electron microscopy was used to confirm the presence of oxSWNHs adsorbed onto the Ti surface, and a quartz crystal microbalance was used to evaluate the binding process during oxSWNH adsorption. The oxSWNHs-ornamented Ti substrate was nontoxic to cells and released biologically active dexamethasone over a sustained period. Conclusion: This oxSWNHs-immobilized system can be used to modify the surface of Ti in implants and be loaded with drugs that stimulate osteogenesis and bone regeneration.
    View publication