Contact
    Start Publications Impact of Multimeric Ferrocene-containing Cyclodecapeptide ...
    ←  Publication Finder
    QSense

    Impact of Multimeric Ferrocene-containing Cyclodecapeptide Scaffold on Host-Guest Interactions at a beta-Cyclodextrin Covered Surface

    Year: 2021

    Journal: ChemPhysChem, Volume 22, NOV 4, page 2231–2239

    Authors: Perez, Enrique Sanchez; Toor, Ritu; Bruyat, Pierrick; Cepeda, Celine; Degardin, Melissa; Dejeu, Jerome; Boturyn, Didier; Coche-Guerente, Liliane

    Organizations: French National Agency (ANR) under FORCELL under LabEx ARCANE [ANR-12-BSVE5-0021]; CBH-EUR-GS [ANR-17-EURE-0003]; University Grenoble Alpes; ICMG [FR2607]

    Keywords: multivalency; cyclodextrin; ferrocene; SAM surface; host-guest interaction

    Among non-covalent bonds, the host-guest interaction is an attractive way to attach biomolecules to solid surfaces since the binding strength can be tuned by the nature of host and guest partners or through the valency of the interaction. For that purpose, we synthesized cyclodecapeptide scaffolds exhibiting in a spatially controlled manner two independent domains enabling the multimeric presentation of guest molecules on one face and the other face enabling the potential grafting of a biomolecule of interest. In this work, we were interested in the beta-cyclodextrin/ferrocene inclusion complex formed on beta-CD monolayers functionalized surfaces. By using surface sensitive techniques such as quartz crystal microbalance and surface plasmon resonance, we quantified the influence of the guest valency on the stability of the inclusion complexes. The results show a drastic enhancement of the affinity with the gradual increase of guest valency. Considering that the sequential binding events are equal and independent, we applied the multivalent model developed by the Huskens group to extract intrinsic binding constants and an effective concentration of host.
    View publication