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    Implant Surfaces Containing Bioglasses and Ciprofloxacin as Platforms for Bone Repair and Improved Resistance to Microbial Colonization

    Year: 2022

    Journal: Pharmaceutics, Volume 14, JUN

    Authors: Negut, Irina; Ristoscu, Carmen; Tozar, Tatiana; Dinu, Mihaela; Parau, Anca Constantina; Grumezescu, Valentina; Hapenciuc, Claudiu; Popa, Marcela; Stan, Miruna Silvia; Marutescu, Luminita; Mihailescu, Ion N.; Chifiriuc, Mariana Carmen

    Organizations: Ministry of Research, Innovation and Digitization, CNCS-UEFISCDI within PNCDI III [PN-III-P1-1.1-PD-2021-0598]

    Keywords: thin film; antibiotic delivery; biocompatibility; bioglass; laser deposition

    Coatings are an attractive and challenging selection for improving the bioperformance of metallic devices. Composite materials based on bioglass/antibiotic/polymer are herein proposed as multifunctional thin films for hard tissue implants. We deposited a thin layer of the polymeric material by matrix-assisted pulsed laser evaporation-MAPLE onto Ti substrates. A second layer consisting of bioglass + antibiotic was applied by MAPLE onto the initial thin film. The antimicrobial activity of MAPLE-deposited thin films was evaluated on Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa standard strains. The biocompatibility of obtained thin films was assessed on mouse osteoblast-like cells. The results of our study revealed that the laser-deposited coatings are biocompatible and resistant to microbial colonization and biofilm formation. Accordingly, they can be considered viable candidates for biomedical devices and contact surfaces that would otherwise be amenable to contact transmission.
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