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    In Situ Electrospinning Wound Healing Films Composed of Zein and Clove Essential Oil

    Year: 2020

    Journal: Macromol. Mater. Eng., Volume 305, MAR

    Authors: Qin, Mei; Mou, Xiao-Ju; Dong, Wen-Hao; Liu, Jia-Xu; Liu, Hao; Dai, Zhang; Huang, Xiao-Wei; Wang, Na; Yan, Xu

    Organizations: National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51703102, 51703103]; Innovation and Entrepreneurship Training Program for College Students of Qingdao University [X2018110650078]

    Keywords: electrospun wound dressings; portable electrospinning devices; wound dressings; zein; clove essential oil fibers

    Electrospun fibrous membranes have the potential to be effective wound dressings for promoting wound healing. However, the fabrication and application of the common electrospun fibrous wound dressings are usually complicated and separated. Here, electrospun zein/clove essential oil (CEO) fibrous membranes are fabricated and applied as a potential wound dressing through in situ electrospinning process by a portable electrospinning device. The in situ electrospinning process can directly electrospin zein/CEO membranes onto a wound site to cover the wound well and improve the convenience and comfort in use. The as-spun zein/CEO membranes show a porous structure and exhibit higher gas permeability at 168.2 +/- 43.3 mm s(-1), with superhydrophilicity to absorb the wound exudate and good biocompatibility as well as antibacterial effects to protect from infection. Moreover, the mice wound model study suggests that in situ electrospun zein/CEO promotes the wound healing process.
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