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    Interaction of Diphenhydramine Hydrochloride with Cationic and Anionic Surfactants: Mixed Micellization and Binding Studies

    Year: 2021

    Journal: Polymers, Volume 13, APR

    Authors: Azum, Naved; Rub, Malik Abdul; Alfaifi, Sulaiman Yahya; Asiri, Abdullah M.

    Organizations: Ministry of Education; King Abdulaziz University, DSR, Jeddah, Saudi Arabia; [IFPHI-013-130-2020]

    Keywords: diphenhydramine hydrochloride; sodium dodecyl sulfate; cetylpyridinium chloride; mixed micellization; binding studies

    The focus of the present work is to evaluate the interactions of an anti-allergic drug (diphenhydramine hydrochloride, DPH) with anionic (sodium dodecyl sulfate, SDS) and cationic (cetylpyridinium chloride, CPC) surfactants in the aqueous medium. The mixed micellization behavior and surface properties of drug-surfactant mixtures have been examined by surface tension measurements. Various theoretical approaches were applied to explore the synergistic or non-ideal behavior of the current mixed systems. Furthermore, the binding studies of drug with surfactants have been elaborated by UV-visible spectroscopy. Benesi-Hildebrand (B-H) theory was used to compute stoichiometric ratio, binding constant, and free energy change for the drug-surfactant mixtures. The outputs are deliberated taking into consideration the use of surfactants as capable drug delivery agents for DPH and hence advance bioavailability.
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