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    Interfacial and spectroscopic behavior of phenothiazine drug/bile salt mixture in urea solution

    Year: 2021

    Journal: Chem. Pap., Volume 75, AUG, page 3949–3956

    Authors: Kumar, Dileep; Azum, Naved; Rub, Malik Abdul; Asiri, Abdullah M.

    Keywords: Phenothiazine drug; Sodium cholate; Urea; Mixed micellization; Surface parameters; UV-visible spectroscopy

    Bile salts are bio-surfactant molecules, anionic in nature, and show an energetic character in cholesterol and lipid solubilization. These amphiphiles are also used as a drug carrier. Being anionic they can interact strongly with other cationic amphiphiles. Keeping in mind this fact, we have investigated the interfacial and spectroscopic performance of cationic phenothiazine drug with bile salt in the nonattendance and attendance 250 mM urea. Surface tension and absorbance (UV-visible spectroscopy) experiments have been performed to elucidate the nature of interactions. The composition and interaction parameters at the interface or surface were computed by using the Rosen theory of mixed monolayer. The other surface parameters were computed by adopting Gibbs adsorption isotherm. Benesi-Hildebrand (B-H) model was utilized to evaluate the binding constant.
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