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    Interfacial Behavior of Fumonisin B1 Toxin and Its Degradation on the Membrane

    Year: 2019

    Journal: Langmuir, Volume 35, 1-Feb, page 2814–2820

    Authors: Sharma, Shiv K.; Sharma, Sijan Poudel; Miller, Darlene; Parel, Jean-Marie A.; Leblanc, Roger M.

    Organizations: NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [GR-009887]; NSFNational Science Foundation (NSF) [GR-011298]; Florida Lions Eye Bank; Beauty of Sight Foundation; University of Miami Scientific Awards Committee Interdisciplinary Team Science Pilot Award (UM SAC 2016-17); D. and Janet K. Robson Foundation; Ophthalmic Biophysics Center

    Fumonisin B1 (FB1), the most abundant component of the fumonisin family, is highly responsible for fungal infections. In this paper, our main aim is to study the surface chemistry and spectroscopic properties of the FB1 molecule and observe the impact of green LED light on the FB1 Langmuir monolayer. From the surface chemistry and spectroscopic studies, we found that the FB1 molecule forms a self-assembled Langmuir monolayer which is sufficient to mimic its interaction with the corneal tissues. The irradiation of green LED light on the FB1. Langmuir monolayer showed the degradation of the FB1 when compared to that in the absence of light. This observation reveals that FB1 molecules lose their tendency to stay as a Langmuir monolayer. The degradation observed on the interface was compared with the bulk phase of FB1. The bulk phase observation also indicated the degradation tendency which reinforced the observed interfacial property of FB1.
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