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    Investigating the Effect of Carbon Nanomaterials Reinforcing Poly(epsilon-Caprolactone) Printed Scaffolds for Bone Repair Applications

    Year: 2020

    Journal: Int. J. Bioprinting, Volume 6, page 61–69

    Authors: Hou, Yanhao; Wang, Weiguang; Bartolo, Paulo

    Organizations: Rosetrees TrustRosetrees Trust [A2750/M874, 298582]; Stoneygate Trust [A2750/M874, 1119976]; University of Manchester; Engineering and Physical Sciences Research Council (EPSRC) of the UK, the Global Challenges Research Fund (GCRF)UK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [EP/R01513/1]

    Keywords: Biomanufacturing; Graphene; Graphene oxide; Poly(epsilon-caprolactone); Scaffolds; Tissue engineering

    Scaffolds, three-dimensional (3D) substrates providing appropriate mechanical support and biological environments for new tissue formation, are the most common approaches in tissue engineering. To improve scaffold properties such as mechanical properties, surface characteristics, biocompatibility and biodegradability, different types of fillers have been used reinforcing biocompatible and biodegradable polymers. This paper investigates and compares the mechanical and biological behaviors of 3D printed poly(epsilon-caprolactone) scaffolds reinforced with graphene (G) and graphene oxide (GO) at different concentrations. Results show that contrary to G which improves mechanical properties and enhances cell attachment and proliferation, GO seems to show some cytotoxicity, particular at high contents.
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