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    Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study

    Year: 2021

    Journal: Polymers, Volume 13, NOV

    Authors: Rub, Malik Abdul; Azum, Naved; Kumar, Dileep; Nadeem Arshad, Muhammad; Khan, Anish; Alotaibi, Maha Moteb; Asiri, Abdullah M.

    Organizations: Institutional Fund Projects [IFPRC-001-130-2020]; Ministry of Education and King Abdulaziz University, Jeddah, Saudi Arabia

    Keywords: imipramine hydrochloride; tensiometry; mixed micelles; interaction parameter; micellar composition

    In this paper, the interaction of imipramine hydrochloride (IMP, antidepressant drug) and a non-ionic surfactant Triton X-100 (TX-100) mixture in five different ratios through the tensiometric method in different solvents (aqueous/0.050 mol & BULL;kg(-1) aqueous NaCl/0.250 mol & BULL;kg(-1) aqueous urea (U)) were examined thoroughly at a temperature of 298 K. UV-Visible studies in an aqueous system of IMP + TX-100 mixtures were also investigated and discussed in detail. The pure (IMP and TX-100) along with the mixtures' critical micelle concentration (cmc) were assessed by a tensiometric technique. The obtained deviation of the mixtures' cmc values from their ideal values revealed the nonideal behavior of IMP + TX-100 mixtures amongst IMP and TX-100. Compared to aqueous systems, in the presence of aqueous NaCl, several changes in micelles/mixed micelles occurred, and hence a synergism/attractive interaction amongst components was found increased while in the existence of U, the synergism/attractive interaction between them decreased. The evaluated interaction parameter (beta(Rb)) value of mixed micelles showed the attractive or synergism between the IMP and TX-100. Various evaluated thermodynamic parameters in an aqueous system showed that the mixed micellization of the IMP + TX-100 mixture was an entropically spontaneous phenomenon, although the existence of salt in all studied systems can somewhat increase the spontaneity of the micellization process and in the aqueous U system, the spontaneity of the micellization process decreased. In an aqueous system, the interaction between IMP and TX-100 was also confirmed by UV-Visible study.
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