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    Magnetic proline-based ionic liquid surfactant as a nano-carrier for hydrophobic drug delivery

    Year: 2020

    Journal: J. Mat. Chem. B, Volume 8, APR 21, page 3050–3057

    Authors: Kulshrestha, Akshay; Gehlot, Praveen Singh; Kumar, Arvind

    Organizations: CSIR-CSMCRICouncil of Scientific & Industrial Research (CSIR) - India [164/2019]; Department of Science and Technology, Government of IndiaDepartment of Science & Technology (India) [EMR/2016/004747]

    Magnetic proline-based surface-active ionic liquid ([ProC(10)][FeCl3Br]) have been synthesized and investigated for their application in hydrophobic drug delivery. Hydrophobic drugs lead to poor absorptivity, drug aggregation, and high local toxicity. Herein, the vesicular structures formed from [ProC(10)][FeCl3Br] have been used as drug delivery reactors. The self-assembly behavior of [ProC(10)][FeCl3Br] in aqueous medium has been investigated using tensiometry, fluorescence, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The physicochemical interactions of [ProC(10)][FeCl3Br] with animal DNA have been studied using circular dichroism (CD), fluorescence, zeta potential, and gel electrophoresis to confirm its bio-friendly nature. The engendered vesicles prepared from [ProC(10)][FeCl3Br] have been investigated for the in vitro drug delivery of guest molecule pyrene as a hydrophobic model drug and ciprofloxacin as a hydrophobic antibiotic drug. The drug loading capacity and spontaneous kinetic release of the drug have been studied using various theoretical mathematical drug release models.
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