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    Materials Based on Quaternized Polysulfones with Potential Applications in Biomedical Field: Structure-Properties Relationship

    Year: 2022

    Journal: Int. J. Mol. Sci., Volume 23, MAY

    Authors: Bargan, Alexandra; Onofrei, Mihaela Dorina; Stoica, Iuliana; Doroftei, Florica; Dunca, Simona; Filimon, Anca

    Organizations: Romanian Ministry of Education and Research, CCCDI-UEFISCDI, within PNCDI III [PN-III-P2-2.1-PED-2019-3013]; Ministry of Research, Innovation and Digitization, CNCS/CCCDI-UEFISCDI, within PNCDI III [PN-III-P2-2.1-PED-2019-3013]

    Keywords: quaternized polysulfones; cellulose acetate phthalate; polyvinyl alcohol; electrospun fibers; surface properties; membrane permeability; antibacterial activity

    Starting from the bactericidal properties of functionalized polysulfone (PSFQ) and due to its excellent biocompatibility, biodegradability, and performance in various field, cellulose acetate phthalate (CAP) and polyvinyl alcohol (PVA), as well as their blends (PSFQ/CAP and PSFQ/PVA), have been tested to evaluate their applicative potential in the biomedical field. In this context, because the polymer processing starts from the solution phase, in the first step, the rheological properties were followed in order to assess and control the structural parameters. The surface chemistry analysis, surface properties, and antimicrobial activity of the obtained materials were investigated in order to understand the relationship between the polymers' structure-surface properties and organization form of materials (fibers and/or films), as important indicators for their future applications. Using the appropriate organization form of the polymers, the surface morphology and performance, including wettability and water permeation, were improved and controlled-these being the desired and needed properties for applications in the biomedical field. Additionally, after antimicrobial activity testing against different bacteria strains, the control of the inhibition mechanism for the analyzed microorganisms was highlighted, making it possible to choose the most efficient polymers/blends and, consequently, the efficiency as biomaterials in targeted applications.
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