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    Mechanical, Biological, and Antibacterial Characteristics of Plasma-Sprayed (Sr,Zn) Substituted Hydroxyapatite Coating

    Year: 2020

    Journal: ACS Biomater. Sci. Eng., Volume 6, MAR, page 1355–1366

    Authors: Ullah, Ihsan; Siddiqui, Muhammad Ali; Liu, Hui; Kolawole, Sharafadeen Kunle; Zhang, Ji; Zhang, Shuyuan; Ren, Ling; Yang, Ke

    Organizations: National Key Research and Development Program of China [2018YFC1106601, 2016YFC1100600]; National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [51631009]; Youth Innovation Promotion Association, CAS [2014168]; Promoting Liaoning Province Talents Program-Top Young Talents [XLYC1807069]

    Keywords: HA coating plasma spray; heat treatment; antibacterial properties; biocompatibility

    Implant-related infections are a major concern in total joint prostheses, occurring up to 3% in operations. In this work, 5% Zn2+ was added in I-TA to offset bacterial activity and 5% Sr2+ was also incorporated as a binary dopant to reduce the cytotoxic effect of Zn2+. The nanosized HA powder was synthesized by the hydrothermal method and then heat-treated at 600 degrees C for 4 h. The heat-treated powder was plasma-sprayed on a titanium alloy Ti-6Al-4V substrate. The addition of the dopant did not significantly influence the physical and mechanical properties of the coating. However, the cytocompatibility, antimicrobial, and contact-angle properties statistically enhanced. Moreover, the (Sr,Zn)-HA coating was post-heat treated at 500 and 600 degrees C for 3 h. X-ray diffraction confirmed that after heat treatment phase purity and crystallinity increased and residual stress decreased. Mechanical stability was evaluated by adhesive bond strength, and the results showed that after heat-treatment bonding strength increased from 26.81 +/- 2.93 to 29.84 +/- 3.62 and 34.66 +/- 2.57 MPa, at 500 and 600 degrees C, respectively. Similar to the mechanical property, antibacterial activities and biological functions are also significantly improved. More interestingly, it was also observed that the Zn2+ ions released from the coating depend on Ca2+, P, and Sr2+ ions while Ca2+, P, and Sr2+ ions relied on heat treatment temperatures. However, (Sr,Zn)-HA coating at 600 degrees C demonstrates cytotoxic effects on MC3T3-E1 cells, characterized by poor cellular morphology on the coating surface and ultimately, cell death. The doping of Sr2+ with Zn2+, therefore, can offset the cytotoxic effects and enhanced biological performance. All of the outcomes of this study signify that (Sr,Zn)-HA coating heat-treated at 500 degrees C showed not only excellent mechanical and biological performance but also enhanced the antibacterial properties.
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