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    Modified suture-assisted canaloplasty in Asians with primary open-angle glaucoma: a prospective study with 12-month follow-up

    Year: 2022

    Journal: BMC Ophthalmol., Volume 22, MAY 4

    Authors: Liang, Ya; Yu, Qiuli; Sun, Hong; Sucijanti; Gu, Liuwei; Yuan, Zhilan

    Organizations: National Natural Science Foundation of China [82101122]; Natural Science Foundation of Jiangsu Province [BK20201085]

    Keywords: Canaloplasty; Suture; Viscocanalostomy; Schlemm's canal; Primary open-angle glaucoma

    Background: To evaluate the efficacy and safety of modified suture-assisted canaloplasty in Asians with primary open-angle glaucoma (POAG). Methods: A prospective, consecutive cases study, evaluating a modified canaloplasty by twisted 6/0 suture was performed on Asian POAG patients. Three modifications of this canaloplasty included opening the Schlemm's canal by viscocanalostomy, circumferential probing by a twisted 6/0 suture and loose suture of the superficial scleral flap. The twisted 6/0 suture was selected as a prober based on characteristical analysis of size and contact measurement as well as chemical composition conducted among 5/0, twisted 6/0 polypropylene sutures and the microcatheter. Success criteria were defined as intraocular pressure (IOP) <= 21 mmHg, 18 mmHg, 15 mmHg, and >= 20% reduction without (complete success) or with medications (qualified success). Efficacy was assessed by the success rate of circumferential catheterization, lOP values, the success rate of the surgery, the number of lOP-lowering medications, best-corrected vision acuity (BCVA), cup-to-disc ratio (C/D), and mean deviation (MD). Safety was evaluated by adverse events. Results: Forty eyes from 40 consecutive patients were included with a mean follow-up of 14.8 +/- 3.0 months. Circumferential catheterization was successfully conducted in 36 eyes (90%). Mean IOP decreased from 26.2 +/- 6.9 mmHg to 14.5 +/- 2.7 mmHg at 12 months postoperatively. While medication numbers were reduced from 3.2 +/- 0.6 to 0.5 +/- 0.8 at month 12 (both p< 0.001). Qualified success rate was 97.2% [95% confidence interval (CI) 0.92-1.03], 86.1% (95% CI 0.74-0.98) and 66.7% (95% CI 0.51-0.83) at 12 months with three criteria. BCVA, C/D and MD did not show progression at 1-year follow-up (p > 0.05). Age, baseline IOP, and spherical equivalent negatively influenced the success rate significantly (all p < 0.05). Adverse events included hyphema (30.6%), IOP spike >25 mmHg (8.3%), and peripheral synechia to the trabecular-Descemet's membrane (2.7%). Conclusion: Twisted 6/0 suture can be an ideal material for cannulation. Modified suture-assisted canaloplasty is an effective, safe alternative with a cost-efficient feature for patients with POAG, especially in developing countries.
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