Contact
    Start Publications Multifunctional Membranes Based on beta-Glucans and Chitosan ...
    ←  Publication Finder
    Attension

    Multifunctional Membranes Based on beta-Glucans and Chitosan Useful in Wound Treatment

    Year: 2022

    Journal: Membranes, Volume 12, FEB

    Authors: Trombino, Sonia; Curcio, Federica; Di Gioia, Maria Luisa; Armentano, Biagio; Poerio, Teresa; Cassano, Roberta

    Organizations: Department of Pharmacy and Health and Nutrition Sciences. Department of Excellence L. 232/2016; PON Health Development and Industrialization of innovative drugs for personalized molecular therapy of Department of Pharmacy and Health and Nutrition Sciences-Unical

    Keywords: chitosan membranes; beta-glucans; wounds; antibacterial properties; antioxidant properties

    In this work, bio-based membranes prepared using a crosslinked beta-glucans-chitosan dispersed in the chitosan matrix useful in promoting wound healing were studied for the first-time. Wound healing is a process that includes sequential steps designed to restore the structure and function of damaged cells and tissue. To minimize damage and the risk of infection during the healing process and to promote restoration of the integrity of damaged tissue, the wound should be dressed. Generally, according to their function in the wound, dressings are classified on the basis of type of material and physical form. The substances used to make a dressing are generally natural polymers such as hydrocolloids, alginates, polyurethane, collagen, chitosan, pectin and hyaluronic acid. The combination of polymeric substances, with antibacterial and antioxidant properties, could be exploited in the biomedical field for the development of biocompatible materials able to act as a barrier between the wound and the external environment, protecting the site from bacterial contamination and promoting healing. To this aim, bio-based membranes were prepared by the phase inversion induced by solvent evaporation, using the crosslinked beta-glucans-chitosan obtained by esterification reactions as a functional additive in the chitosan membrane. The reaction intermediates and the final products were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) while the morphological properties of membranes were analyzed using electronic scanning microscopy (SEM). The chemical bonding between chitosan and beta-glucans allowed for the obtainment of a better dispersion of the combined new material into the membrane's matrix and as a consequence, an enhanced antibacterial property evaluated through in vitro tests, with respect to the starting materials.
    View publication