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    Multifunctional Surface Modification of PDMS for Antibacterial Contact Killing and Drug-Delivery of Polar, Nonpolar, and Amphiphilic Drugs

    Year: 2022

    Journal: ACS Appl. Bio Mater., Volume 5, NOV 2, page 5289–5301

    Authors: Stepulane, Annija; Rajasekharan, Anand Kumar; Andersson, Martin

    Organizations: Knut and Alice Wallenberg foundation; Area of Advance for Materials Science at Chalmers University of Technology; Amferia AB

    Keywords: polydimethylsiloxane; antibacterial coating; antimicrobial peptides; hydrogel microparticles; drug delivery

    Medical device-associated infections pose major clinical challenges that emphasize the need for improved anti infective biomaterials. Polydimethylsiloxane (PDMS), a frequently used elastomeric biomaterial in medical devices, is inherently prone to bacterial attachment and associated infection formation. Here, PDMS surface modification strategy is presented consisting of a cross-linked lyotropic liquid crystal hydrogel microparticle coating with antibacterial functionality. The microparticle coating composed of cross-linked triblock copolymers (diacrylated Pluronic F127) was deposited on PDMS by physical immobilization via interpenetrating polymer network formation. The formed coating served as a substrate for covalent immobilization of a potent antimicrobial peptide (AMP), RRPRPRPRPWWWW-NH2, yielding high contact-killing antibacterial effect against Staphylococcus epidermidis and Staphylococcus aureus. Additionally, the coating was assessed for its ability to selectively host polar, amphiphilic, and nonpolar drugs, resulting in sustained release profiles. The results of this study put forward a versatile PDMS modification strategy for both contact-killing antibacterial surface properties and drug-delivery capabilities, offering a solution for medical device-associated infection prevention.
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