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    Natural Melanin/Polyurethane Composites as Highly Efficient Near-Infrared-Photoresponsive Shape Memory Implants

    Year: 2020

    Journal: ACS Biomater. Sci. Eng., Volume 6, SEP, page 5305–5314

    Authors: Xie, Wanjie; Yang, Fei; Pakdel, Esfandiar; Sharp, Julie; Liu, Dan; Wang, Xungai; Zhan, Shi; Sun, Lu

    Organizations: National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81870117, 21621001]; 111 ProjectMinistry of Education, China - 111 Project [B17020]; Jilin Province Science and Technology Development Plan [20190201252JC]; Australian Government Research Training Program Fees Offset ScholarshipAustralian Government; Deakin University Postgraduate Research Scholarship

    Keywords: natural melanin; near-infrared; photothermal; shape memory; implant

    Natural melanin is recognized as a biocompatible photothermal agent because of its biologically derived nature and efficient photothermal conversion ability. Here, yak hair melanin (YM) is added to polyurethane (PU) for the fabrication of NIR-photoresponsive shape memory implants. The in vitro toxicity of the YM/PU composites is carried out by exposing them to human mesenchymal stem cells (hMSCs) and mouse fibroblast (L929) cells lines for 24 h, while the in vivo toxicity is investigated by implanting the YM/PU composites in the mouse for two months. No significant differences on cell viability, blood chemistry, hematology, and histological results are observed between YM/PU composites and control groups, suggesting their excellent biocompatibility. The biostability of the YM/PU composites is confirmed by monitoring their in vitro degradation for 12 weeks. The YM/PU column implanted in the back subcutis or vagina of the mouse rapidly recovered to its original state within 60 s under a very low NIR laser (808 nm, 0.5 W/cm(2)) intensity, which is much lower than the general laser intensity for photothermal cancer therapy (1-2 W/cm(2)). This work confirms the applicability of the YM/PU composites as long-term implant materials and expedites the use of YM/PU composites as cost-effective candidates for biomedical applications.
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