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    New antimicrobial materials with cerium ions in the composition of salts, solutions, and composite systems based on Ce3+(NO3)(3) x 6H(2)O

    Year: 2022

    Journal: New J. Chem., Volume 46, OCT 17, page 19271–19282

    Authors: Gainanova, Asiya A.; Kuz'micheva, Galina M.; Terekhova, Raisa P.; Pashkin, Igor I.; Trigub, Alexander L.; Malysheva, Natal'ya E.; Svetogorov, Roman D.; Alimguzina, Aliya R.; Koroleva, Alexandra, V

    Organizations: Ministry of Science and Higher Education of the Russian Federation [0706-2020-0026]

    The results of detailed characterization of new antimicrobial materials in the form of Ce(NO3)(3) x 6H(2)O salt with the proposed crystal-chemical composition of [Ce3+(H2O)(4)(NO3)(3)] x 2H(2)O and its aqueous solution by X-ray diffraction (XRD), differential scanning calorimetry (DSC), X-ray photoelectron spectroscopy (XPS), X-ray absorption spectroscopy (XAS) are presented. The stages of [Ce3+(H2O)(4)(NO3)(3)] x 2H(2)O thermal decomposition with the formation of [Ce3+(H2O)(4)(NO3)(3)] (<220 degrees C), Ce3+ONO3 (230-320 degrees C) and Ce4+O2 (>300 degrees C) are shown. It was found that Ce3+ ions in the composition of [Ce(H2O)(4)(NO3)(3)] x 2H(2)O salt and in its aqueous solution retain their formal charge (FC Ce = 3) and coordination number (CNCe = 10, where 6O from three NO3- groups and 4O from four 4H(2)O molecules) with the reorientation of nitro groups in Ce3+ far environment in an aqueous salt solution. It was established that [Ce3+(H2O)(4)(NO3)(3)] x 2H(2)O, [Ce3+(H2O)(4)(NO3)(3)] and Ce3+ONO3 salts inhibit the growth of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa bacteria in the absence of radiation with a growth zone inhibition diameter D > 37 mm with D-max = 45 mm on the multiphase sample ([Ce3+(H2O)(4)(NO3)(3)], Ce3+ONO3, Ce4+O2), which is higher than that on penicillin (D = 12-18 mm). It is shown that an increase in the [Ce3+(H2O)(4)(NO3)(3)] x 2H(2)O salt concentration in an aqueous solution has a positive effect on antimicrobial activity. It is not excluded that the absence of interaction of Ce3+ ions in the salt solution with Langmuir phospholipid monolayers of phosphatidylethanolamine (DPPE) and phosphatidylglycerin (DPPG) is associated with the damage to the protein component of the bacterial membrane and not with the phospholipid one and/or with the penetration of Ce3+ ions into the cell and violation of its water-ionic balance. It is shown that the H-Beta - Ce3+(NO3)(3) x 6H(2)O system fabrication with biocompatible H-Beta zeolite contributes to the preservation of antimicrobial activity in the dark (Pseudomonas aeruginosa) with a decrease in the amount of the active component.
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