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    Novel biohybrid spongy scaffolds for fabrication of suturable intraoral graft substitutes

    Year: 2022

    Journal: Int. J. Biol. Macromol., Volume 214, AUG 1, page 617–631

    Authors: Mehwish, Nabila; Chen, Yuan; Zaeem, Muhammad; Wang, Yi; Lee, Bae Hoon; Deng, Hui

    Organizations: Wenzhou Institute, University of Chi- nese Academy of Sciences [WIUCASQD2019003]; Zhejiang Provincial Public Welfare Technology Applied Research Project [LGF19H140005, LGF21H140006]; Public Welfare Science and Technology Plan of Wenzhou City [Y20190106]

    Keywords: Cryogel; Intraoral graft substitute; Gelatin methacryloyl; Albumin methacryloyl; Tissue engineering

    Despite the fact that classic autograft is the gold standard material for periodontal plastic surgery, it has some drawbacks, including the need for a second surgical site and the scarcity of palatal donor tissues. However, only a few research works on the manufacturing of bioengineered intraoral connective tissue grafts have been conducted. In this work, porous bovine serum albumin methacryloyl/gelatin methacryloyl (BG) biohybrid scaffolds were developed for super-elasticity, shape recovery, suturability for persistent stability, sufficient scaffolding function, and convenient manipulating characteristics to fabricate an intraoral graft substitute with superb stability to resist frequent dynamic forces caused by functional movement (speaking, masticating, and swallowing). Furthermore, in a 3D cell culture assay, BG scaffolds demonstrated excellent cell adhesion and proliferation of L929 cells. In addition, the BG scaffolds were able to release Ibuprofen in a controlled manner for postoperative recovery. The use of a low-cost, optimized cryogelation technique for functional biomacromolecules offers up new possibilities to develop promising scaffolds for dental clinical settings.
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