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    Oral Films with Addition Mushroom (Agaricus bisporus) as a Source of Active Compounds

    Year: 2022

    Journal: J. Pharm. Sci., Volume 111, JUN, page 1739–1748

    Authors: Garcia, Vitor Augusto dos Santos; Osiro, Denise; Vanin, Fernanda Maria; Yoshida, Cristiana Maria Pedroso; Carvalho, Rosemary Aparecida de

    Organizations: Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Brazil

    Keywords: Phenolic compounds; FTIR analyses; Natural compounds

    The purpose of this study was to develop oral films (OFs) based on agar-agar with the incorporation of mushroom powder (MP) as a source of phenolic compounds. To this end, three different OFs were produced using different concentrations of MP, containing sorbitol and agar-agar. The OFs were characterized based on visual assessment, mass, thickness, moisture content, folding endurance, surface pH, contact angle, and phenolic compound content, scanning electron microscopy, X-ray diffraction, and FTIR, as well as an assessment of their antioxidant capacity. In general, all the OFs showed film-forming capacity after the incorporation of MP, although their mass, thickness, moisture content, and folding endurance differed significantly. The surface pH value remained close to neutrality (>> 6.7), regardless of MP concentration. The incorporation of MP increased the crystallinity of the OFs in comparison to that of the agar-based film, but all the OFs showed similar FTIR spectra. The oral films containing 2 g of MP showed antioxidant capacity by ABTS*+ and FRAP of 3.68 +/- 0.23 and 14.61 +/- 0.66 mMol ET/g OF, respectively, and total phenolic content of 3.55 +/- 0.27 mmol GAE/g OF. Thus, oral films offer an innovative source of delivery of active compounds, and their consumption does not cause oral mucosal irritation. (c) 2021 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.
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