Contact
    Start Publications Osseointegration and antibacterial effect of an antimicrobial ...
    ←  Publication Finder
    Attension

    Osseointegration and antibacterial effect of an antimicrobial peptide releasing mesoporous titania implant

    Year: 2021

    Journal: J. Biomed. Mater. Res. Part B, Volume 109, NOV, page 1787–1795

    Authors: Pihl, Maria; Galli, Silvia; Jimbo, Ryo; Andersson, Martin

    Organizations: Knut och Alice Wallenbergs Stiftelse

    Keywords: biofilm; rabbit tibia model; Staphylococcus epidermidis; sustained release

    Medical devices such as orthopedic and dental implants may get infected by bacteria, which results in treatment using antibiotics. Since antibiotic resistance is increasing in society there is a need of finding alternative strategies for infection control. One potential strategy is the use of antimicrobial peptides, AMPs. In this study, we investigated the antibiofilm effect of the AMP, RRP9W4N, using a local drug-delivery system based on mesoporous titania covered titanium implants. Biofilm formation was studied in vitro using a safranine biofilm assay and LIVE/DEAD staining. Moreover, we investigated what effect the AMP had on osseointegration of commercially available titanium implants in vivo, using a rabbit tibia model. The results showed a sustained release of AMP with equal or even better antibiofilm properties than the traditionally used antibiotic Cloxacillin. In addition, no negative effects on osseointegration in vivo was observed. These combined results demonstrate the potential of using mesoporous titania as an AMP delivery system and the potential use of the AMP RRP9W4N for infection control of osseointegrating implants.
    View publication