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    P34HB electrospun fibres promote bone regeneration in vivo

    Year: 2019

    Journal: Cell Prolif., Volume 52, MAY

    Authors: Fu, Na; Meng, Zhaosong; Jiao, Tiejun; Luo, Xiaoding; Tang, Zisheng; Zhu, Bofeng; Sui, Lei; Cai, Xiaoxiao

    Organizations: National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81800930, 81771125, 81471803]; Science & Technology Development Fund of Tianjin Education Commission for Higher Education [2017KJ217]

    Keywords: bone marrow mesenchymal stem cells; bone tissue engineering; calvarial defects; electrospinning; P34HB

    Objective Bone tissue engineering was introduced in 1995 and provides a new way to reconstruct bone and repair bone defects. However, the design and fabrication of suitable bionic bone scaffolds are still challenging, and the ideal scaffolds in bone tissue engineering should have a three-dimensional porous network, good biocompatibility, excellent biodegradability and so on. The purpose of our research was to investigate whether a bioplasticpoly3-hydroxybutyrate4-hydroxybutyrate (P34HB) electrospun fibre scaffold is conducive to the repair of bone defects, and whether it is a potential scaffold for bone tissue engineering. Materials and methods The P34HB electrospun fibre scaffolds were prepared by electrospinning technology, and the surface morphology, hydrophilicity, mechanical properties and cytological behaviour of the scaffolds were tested. Furthermore, a calvarial defect model was created in rats, and through layer-by-layer paper-stacking technology, the P34HB electrospun fibre scaffolds were implanted into the calvarial defect area and their effect on bone repair was evaluated. Results The results showed that the P34HB electrospun fibre scaffolds are interwoven with several fibres and have good porosity, physical properties and chemical properties and can promote cell adhesion and proliferation with no cytotoxicity in vitro. In addition, the P34HB electrospun fibre scaffolds can promote the repair of calvarial defects in vivo. Conclusions These results demonstrated that the P34HB electrospun fibre scaffold has a three-dimensional porous network with good biocompatibility, excellent biosafety and ability for bone regeneration and repair; thus, the P34HB electrospun fibre scaffold is a potential scaffold for bone tissue engineering.
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