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    Poly(2-methoxyethyl acrylate) coated bioprosthetic heart valves by copolymerization with enhanced anticoagulant, anti-inflammatory, and anti-calcification properties

    Year: 2022

    Journal: J. Mat. Chem. B, Volume 10, DEC 14, page 10054–10064

    Authors: Liang, Xuyue; Lei, Yang; Ding, Kailei; Huang, Xueyu; Zheng, Cheng; Wang, Yunbing

    Organizations: Chengdu Major Science and Technology Innovation Programs [2019-YF08-00235-GX]; CAMS Innovation Fund for Medical Sciences [2021-I2M-5-013]; National Natural Science Foundation of China [32071357]; Sichuan Science and Technology Program [2021YFH0011]; National Key Research and Development Programs, China [2020YFC1107802]; 111 Project of Introducing Talents of Discipline to Universities, China [B16033]

    Commercial glutaraldehyde (Glut) cross-linked bioprosthetic heart valves (BHVs) fabricated from the pericardium have become the most popular choice for treating heart valve diseases. Nevertheless, thrombosis, inflammation and calcification might lead to structural valve degeneration (SVD), which limited the durability of BHVs. Herein, to improve the biocompatibility of BHVs, we fabricated a poly-(2-methoxyethyl acrylate) (PMEA) coated porcine pericardium (PMEA-PP) through grafting PMEA to the porcine pericardium (PP) that was pre-treated with Glut and methacrylated polylysine. PMEA coating mitigated the side effects caused by aldehyde residues. It was shown that the PMEA coating reduced cytotoxicity and inflammation reactions and improved endothelialization potential, and its hydrophilic surface improved the anti-thrombotic properties of PPs. And the PMEA coating significantly reduced the calcification of PPs. This strategy promoted the endothelialization potential and improve the anti-thrombosis and anti-calcification properties of BHVs, and is expected to overcome the defects of commercial BHVs.
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