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    Poly(trimethylene carbonate) flexible intestinal anastomosis scaffolds to reduce the probability of intestinal fistula and obstruction

    Year: 2021

    Journal: J. Mat. Chem. B, Volume 9, JUL 14, page 5340–5351

    Authors: Ren, Yuehan; Li, Xujian; Wu, Lei; Pan, Luqi; Ji, Zhixiao; Shi, Changcan; Zhang, Xiaodong

    Organizations: Wenzhou Science and Technology Major Project [ZY2019018]; Wenzhou Institute, University of Chinese Academy of Sciences startup fund [WIUCASQD2019006]; Zhejiang Province Welfare Technology Applied Research Project [LGF20C100002]; Health Bureau of Zhejiang Province [2019RC203]

    Biodegradable anastomat play an important role in the reconstruction process of the digestive tract. However, the biocompatibility and organizational compliance of anastomotic tubes still need to be improved. Electrospun tissue engineering scaffolds have excellent biomimetic extracellular matrix properties, biocompatibility and biodegradability. In the present study, electrospun poly(trimethylene carbonate) (PTMC) intestinal anastomosis scaffolds loaded with triclosan (TCS) were reported to reduce the probability of intestinal fistula and obstruction. When the viscosity average molecular weight of PTMC was 157 x 10(3), the elastic modulus and tensile strength of the anastomosis scaffolds could reach 20.11 MPa and 16.08 MPa, respectively, which indicated that the anastomosis scaffolds exhibited excellent tensile flexibility. The degradation of PTMC was accelerated with the increase of M-w. After 28 days, the weight and length of the anastomosis scaffolds reduced 40% and 50%, respectively. Furthermore, the application of PTMC anastomosis scaffolds could promote intestinal healing and reduce the probability of intestinal fistula and obstruction.
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