Contact
    Start Publications Preparation and Characterization of Poly(ethylene-co-vinyl ...
    ←  Publication Finder
    Attension

    Preparation and Characterization of Poly(ethylene-co-vinyl alcohol)/poly(epsilon-caprolactone) Blend for Bioscaffolding Applications

    Year: 2020

    Journal: Int. J. Mol. Sci., Volume 21, AUG

    Authors: Alghamdi, Abdulaziz Ali; Alattas, Hussain; Saeed, Waseem Sharaf; Al-Odayni, Abdel-Basit; Alrahlah, Ali; Aouak, Taieb

    Organizations: Deanship of Scientific Research at King Saud UniversityKing Saud University [RGP-1438-040]

    Keywords: poly(ethylene-co-vinyl alcohol)/poly(epsilon-caprolactone) miscibility; thermal properties; mechanical properties; surface wettability; cell adhesion; pore interconnection

    In order to improve the cell adhesion on poly(epsilon-caprolactone) (PCL) scaffolds, poly(ethylene-co-vinyl alcohol) (E-VAL) which has hydroxyl groups capable of developing hydrogen bonds with celling was blended with this polymer. To reach this goal, a series of E-VAL/PCL blends with different compositions were prepared by the solvent casting method. The miscibility of the polymer blend was proved by differential scanning calorimetry and Fourier-transform infrared spectroscopy spectrometry. Furthermore, the mechanical properties of the polymer blends were assessed in their wet state by dynamic mechanical analysis. The surfaces wettability of blends and their components were examined through static contact angle measurements. The pore interconnections in the resulted scaffolds were achieved by the incorporation of naphthalene microparticles which were used as porogen and then removed in its gas state by sublimation under reduced pressure. The presence of pores interconnected inside the polymeric materials and their surface morphologies was examined by scanning electron microscopy. The in-vitro cytotoxicity and cell adhesion on the prepared materials were examined by an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.
    View publication