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    Preparation, characterization and antimicrobial activity evaluation of electrospun PCL nanofiber composites of resveratrol nanocrystals

    Year: 2020

    Journal: Pharm. Dev. Technol., Volume 25, NOV 25, page 1216–1225

    Authors: Karakucuk, Alptug; Tort, Serdar

    Organizations: Republic of Turkey Ministry of Industry and Technology [0104]

    Keywords: Resveratrol; nanocrystal; nanofiber; solubility enhancement; dermal delivery

    The objective of this study was to develop resveratrol nanocrystals to solve low water solubility issues of resveratrol and adsorb them to the polycaprolactone nanofibers. Nanocrystals were prepared by microfluidization. Particle size, polydispersity index and zeta potential values were evaluated as dependent variables. Polycaprolactone (PCL) nanofibers were prepared via electrospinning method and the flow rate, electrical voltage and tip-to-collector distance were set to 3 mL/h, 13 kV and 15 cm, respectively. Optimum resveratrol nanocrystals were lyophilized and re-suspended in water and physically adsorbed to PCL nanofibers with two different concentrations (0.2 and 1 mg/cm(2)). Bioadhesion, wettability, solubility, drug loading and antimicrobial activity againstPropionibacterium acnesstudies were carried out. Final nanocrystals showed 800 nm of particle size, 0.4 of polydispersity index, and -8 mV of zeta potential. Nanocrystals successfully adsorbed to PCL nanofibers proven on SEM images with adsorption efficiencies >70%. Adsorption of resveratrol nanocrystals decreased the contact angle of PCL from 128 degrees to 50 degrees. The solubility of resveratrol nanocrystals enhanced similar to 5-fold in comparison with coarse powder. Effective antimicrobial activity againstP. acneswas observed. It is concluded that nanocrystal loading on nanofibers brings advantage into preparing easy to use dermal patches for acne treatment or skin disorders.
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