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    Preparing printable bacterial cellulose based gelatin gel to promote in vivo bone regeneration

    Year: 2021

    Journal: Carbohydr. Polym., Volume 270, OCT 15

    Authors: Wang, Xucai; Tang, Shijia; Chai, Senlin; Wang, Peng; Qin, Jianghui; Pei, Wenhui; Bian, Huiyang; Jiang, Qing; Huang, Caoxing

    Organizations: Young Elite Scientists Sponsorship Program by CAST; Qinglan project of Jiangsu Province; National Natural Science Foundation of China [81972124]; Natural Science Foundation of Jiangsu Province [20170123]

    Keywords: Bacterial cellulose; Maleic acid treatment; 3D printing bioink; Osteoblast differentiation; Bone regeneration

    The naturally tight entanglement of fibers in bacterial cellulose (BC) results in low printability when BC is used as a bioink for printing scaffolds. In this study, neat BC was treated by TEMPO-mediated oxidation (TO-BC) and maleic acid (MA-BC) to prepare homogeneous BC dispersions to fabricate scaffolds for bone regeneration. Results showed that the treatments released individual fibrils in the corresponding uniform dispersions without impairing inherent crystalline properties. Compared with TO-BC, MA-BC hybridized with gelatin could endow the gel with improved rheological properties and compression modulus for 3D printing. Both TO-BC and MA-BC dispersions showed good osteoblast viability. However, MA-BC possessed more pronounced ability to express osteogenic marker genes and formation of mineralized nodules in vitro. Compared with TO-BC-based gelatin scaffolds, MA-BC-based gelatin scaffolds showed a better ability to stimulate the regeneration of rat calvaria, demonstrating a higher bone mineral density of newly formed bone and trabecular thickness in vivo.
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