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    Properties of Langmuir and immobilized layers of betulin diphosphate on aqueous solutions of zinc sulfate and on the surface of zinc oxide nanoparticles

    Year: 2021

    Journal: Russ. Chem. Bull., Volume 70, FEB, page 289–300

    Authors: Melnikova, N. B.; Malygina, D. S.; Vorobyova, O. A.; Solovyeva, A. G.; Belyaeva, K. L.; Orekhov, D. V.; Knyazev, A. V.

    Organizations: Ministry of Higher Education and Science of the Russian Federation [0729-2020-0039]

    Keywords: betulin diphosphate; immobilization; zinc oxide nanoparticles; Langmuir monolayers

    This work examines the specific features of interaction of betulin diphosphate (BDP), exhibiting antitumor and wound-healing properties, with zinc cations during its immobilization on ZnO nanoparticles. The properties of Langmuir and transferred BDP monolayers from an aqueous subphase of zinc sulfate onto the surface of a solid substrate (CaF2, quartz) by the Langmuir-Schaefer method are investigated using IR and UV spectroscopy. It is shown that there is a twofold increase of the molecular area in the immobilized layers, while the compressibility modulus decreases by a factor of 1.5. Zinc oxide nanoparticles with immobilized BDP 10-20 nm in size (surface concentration of BDP is 100 mg g(-1)) retain the original hexagonal wurtzite structure. The efficiency of betulin diphosphate immobilized on the surface of zinc oxide nanoparticles is demonstrated in in vivo experiments for burn wounds in rats.