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    RGD-Modified Titanium as an Improved Osteoinductive Biomaterial for Use in Dental and Orthopedic Implants

    Year: 2022

    Journal: Bioconjugate Chem., Volume 33, FEB 16, page 294–300

    Authors: Seemann, Alexandra; Akbaba, Sema; Buchholz, Jessica; Tuerkkan, Sibel; Tezcaner, Aysen; Woche, Susanne K.; Guggenberger, Georg; Kirschning, Andreas; Draeger, Gerald

    Organizations: BIOFABRICATION FOR NIFE initiative - ministry of Lower Saxony; Volkswagen Stiftung; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [EXC 62]

    This study describes the synthesis, surface analysis, and biological evaluation of bioactive titanium surfaces. The aim was to achieve an improved effect on osteoinduction in dental and orthopedic implants. For this purpose, a chemistry was developed, which allows to bind the bioactive cyclopeptide cRGDfK covalently to biomedically used titanium via polyethylene glycol linkers of different lengths. The chemical process is practicable, robust, and metal-free. The resulting chemically modified titanium plates show improved osteoinductive properties. The modification with cRGDfK targets the integrin alpha(v)beta(3), which is highly expressed in osteoblasts and is essential for many basic functions in the development of bone tissue. The successful immobilization of cRGDfK on titanium surfaces has been demonstrated by contact angle measurements and X-ray photoelectron spectroscopy. We show in in vitro studies that the presence of the cRGDfK peptide on titanium surfaces has a positive effect on bone formation.
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