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    Role of Iron Phthalocyanine Coordination in Catecholamines Detection

    Year: 2021

    Journal: Surfaces, Volume 4, DEC, page 323–335

    Authors: Martin, Cibely S.; Rubira, Rafael J. G.; Silva, Jaqueline N.; Alessio, Priscila

    Organizations: FAPESP [2014/50869-6, 2017/06534-8, 2017/15019-0, 2020/05423-0]; CNPq [422163/2018-0, 304836/2018-4]; CAPES; National Institute for Science and Technology on Organic Electronics (INEO) [465572/2014-6]; [CAPES 23038.000776/201754]

    Keywords: catecholamines; iron coordination; phthalocyanines; electrochemical sensing

    Catecholamines are an important class of neurotransmitters responsible for regularizing, controlling, and treating neural diseases. Based on control and diseases treatment, the development of methodology and dives to sensing is a promissory technology area. This work evaluated the role of iron phthalocyanine coordination (FePc) with the specific groups from catecholamine molecules (L-dopa, dopamine, epinephrine, and the amino acid tyrosine) and the effect of this coordination on electrochemical behavior. The in situ coordination analysis was performed through isotherms pi-A of FePc Langmuir films in the absence and presence of catecholamines. The pi-A isotherm indicates a strong interaction between FePc monolayer and L-Dopa and DA, which present a catechol group and a side chain with a protonated amino group (-NH3+). These strong interactions with catechol and amine groups were confirmed by characterization at the molecular level using the surface-enhanced Raman spectroscopy (SERS) from a Langmuir-Schaefer monolayer deposited onto Ag surfaces. The electrochemical measurements present a similar tendency, with lower oxidation potential observed to DA>L-Dopa>Ep. The results corroborate that the coordination of the analyte on the electron mediator surface plays an essential role in an electrochemical sensing application. The FePc LS film was applied as a sensor in tablet drug samples, showing a uniformity of content of 96% for detecting active compounds present in the L-Dopa drug samples.
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