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    Self-adhesive lubricated coating for enhanced bacterial resistance

    Year: 2021

    Journal: Bioact. Mater., Volume 6, AUG, page 2535–2545

    Authors: Han, Ying; Zhao, Weiwei; Zheng, Yiwei; Wang, Haimang; Sun, Yulong; Zhang, Yifei; Luo, Jing; Zhang, Hongyu

    Organizations: National Natural Science Foundation of China [52022043]; Tsinghua University Initiative Scientific Research Program [20197050026]; Precision Medicine Foundation, Tsinghua University, China [10001020120]; Capital's Funds for Health Improvement and Research [2020-2Z-40810]; Research Fund of State Key Laboratory of Tribology, Tsinghua University, China [SKLT2020C11]

    Keywords: Dopamine; Lubrication; Biomimetic coating; Bacterial resistance; Self-adhesive

    Limited surface lubrication and bacterial biofilm formation pose great challenges to biomedical implants. Although hydrophilic lubricated coatings and bacterial resistance coatings have been reported, the harsh and tedious synthesis greatly compromises their application, and more importantly, the bacterial resistance property has seldom been investigated in combination with the lubrication property. In this study, bioinspired by the performances of mussel and articular cartilage, we successfully synthesized self-adhesive lubricated coating and simultaneously achieved optimal lubrication and bacterial resistance properties. Additionally, we reported the mechanism of bacterial resistance on the nanoscale by studying the adhesion interactions between biomimetic coating and hydrophilic/hydrophobic tip or living bacteria via atomic force microscopy. In summary, the selfadhesive lubricated coating can effectively enhance lubrication and bacterial resistance performances based on hydration lubrication and hydration repulsion, and represent a universal and facial strategy for surface functionalization of biomedical implants.
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