Contact
    Start Publications Smart Biointerface with Photoswitched Functions between ...
    ←  Publication Finder
    QSense

    Smart Biointerface with Photoswitched Functions between Bactericidal Activity and Bacteria-Releasing Ability

    Year: 2017

    Journal: ACS Appl. Mater. Interfaces, Volume 9, AUG 9, page 25767–25774

    Authors: Wei, Ting; Zhan, Wenjun; Yu, Qian; Chen, Hong

    Keywords: antibacterial sulfate; host-guest interaction; photoresponsive; dynamic biointerface; bacterial release

    Smart biointerfaces with capability to regulate cell surface interactions in response to external stimuli are of great interest for both fundamental research and practical applications. Smart surfaces with ON/OFF switchability for a single function such as cell attachment/detachment are well-known and useful, but the ability to switch between two different functions may be seen as the next level of smart. In this work reported, a smart supramolecular surface capable of switching functions reversibly between bactericidal activity and bacteria-releasing ability in response to UV-visible light is developed. This platform is composed of surface-containing azobenzene (Azo) groups and a biocidal beta-cyclodextrin derivative conjugated with seven quaternary ammonium salt groups (CD-QAS). The surface-immobilized Azo groups in trans form can specially incorporate CD-QAS to achieve a strongly bactericidal surface that kill more than 90% attached bacteria. On irradiation with UV light, the Azo groups switch to cis form, resulting in the dissociation of the Azo/CD-QAS inclusion complex and release of dead bacteria from the surface. After the kill-and-release cycle, the surface can be easily regenerated for reuse by irradiation with visible light and reincorporation of fresh CD-QAS. The use of supramolecular chemistry represents a promising approach to the realization of smart, multifunctional surfaces, and has the potential to be applied to diverse materials and devices in the biomedical field.
    View publication